Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study
Identifieur interne : 001308 ( Main/Exploration ); précédent : 001307; suivant : 001309Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study
Auteurs : Ronald B. Postuma [Canada] ; Josie-Anne Bertrand [Canada] ; Jacques Montplaisir [Canada] ; Catherine Desjardins [Canada] ; Mélanie Vendette [Canada] ; Silvia Rios Romenets [Canada] ; Michel Panisset [Canada] ; Jean-François Gagnon [Canada]Source :
- [ 0885-3185 ]
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Behavior, Cross-Sectional Studies, Dementia, Dementia (complications), Dementia (diagnosis), Dementia (epidemiology), Female, Humans, Incidence, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson disease, Polysomnography, Prospective, Prospective Studies, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (epidemiology), Rapid eye movement sleep, Risk, Risk factor, Sleep disorder.
- MESH :
- complications : Dementia, Parkinson Disease, REM Sleep Behavior Disorder.
- diagnosis : Dementia, REM Sleep Behavior Disorder.
- epidemiology : Dementia, REM Sleep Behavior Disorder.
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Incidence, Male, Middle Aged, Neuropsychological Tests, Polysomnography, Prospective Studies, Risk.
Abstract
One of the most devastating nonmotor manifestations of PD is dementia. There are few established predictors of dementia in PD. In numerous cross‐sectional studies, patients with rapid eye movement (REM) sleep behavior disorder (RBD) have increased cognitive impairment on neuropsychological testing, but no prospective studies have assessed whether RBD can predict Parkinson's dementia. PD patients who were free of dementia were enrolled in a prospective follow‐up of a previously published cross‐sectional study. All patients had a polysomnogram at baseline. Over a mean 4‐year follow‐up, the incidence of dementia was assessed in those with or without RBD at baseline using regression analysis, adjusting for age, sex, disease duration, and follow‐up duration. Of 61 eligible patients, 45 (74%) were assessed and 42 were included in a full analysis. Twenty‐seven patients had baseline RBD, and 15 did not. Four years after the initial evaluation, 48% with RBD developed dementia, compared to 0% of those without (P‐adjusted = 0.014). All 13 patients who developed dementia had mild cognitive impairment on baseline examination. Baseline REM sleep atonia loss predicted development of dementia (% tonic REM = 73.2 ± 26.7 with dementia, 40.8 ± 34.5 without; P = 0.029). RBD at baseline also predicted the new development of hallucinations and cognitive fluctuations. In this prospective study, RBD was associated with increased risk of dementia. This indicates that RBD may be a marker of a relatively diffuse, complex subtype of PD. © 2012 Movement Disorder Society
Url:
DOI: 10.1002/mds.24939
Affiliations:
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Le document en format XML
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Sommeil, Hôpital du Sacré‐Coeur de Montréal, 5400 boulevard Gouin ouest, Montréal, Québec H4J 1C5</wicri:regionArea><wicri:noRegion>Québec H4J 1C5</wicri:noRegion></affiliation></author></analytic><series><idno type="ISSN">0885-3185</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Behavior</term><term>Cross-Sectional Studies</term><term>Dementia</term><term>Dementia (complications)</term><term>Dementia (diagnosis)</term><term>Dementia (epidemiology)</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Polysomnography</term><term>Prospective</term><term>Prospective Studies</term><term>REM Sleep Behavior Disorder (complications)</term><term>REM Sleep Behavior Disorder (diagnosis)</term><term>REM Sleep Behavior Disorder (epidemiology)</term><term>Rapid eye movement sleep</term><term>Risk</term><term>Risk factor</term><term>Sleep disorder</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dementia</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Polysomnography</term><term>Prospective Studies</term><term>Risk</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term><term>Démence</term><term>Facteur risque</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Prospective</term><term>Sommeil paradoxal</term><term>Trouble du sommeil</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One of the most devastating nonmotor manifestations of PD is dementia. There are few established predictors of dementia in PD. In numerous cross‐sectional studies, patients with rapid eye movement (REM) sleep behavior disorder (RBD) have increased cognitive impairment on neuropsychological testing, but no prospective studies have assessed whether RBD can predict Parkinson's dementia. PD patients who were free of dementia were enrolled in a prospective follow‐up of a previously published cross‐sectional study. All patients had a polysomnogram at baseline. Over a mean 4‐year follow‐up, the incidence of dementia was assessed in those with or without RBD at baseline using regression analysis, adjusting for age, sex, disease duration, and follow‐up duration. Of 61 eligible patients, 45 (74%) were assessed and 42 were included in a full analysis. Twenty‐seven patients had baseline RBD, and 15 did not. Four years after the initial evaluation, 48% with RBD developed dementia, compared to 0% of those without (P‐adjusted = 0.014). All 13 patients who developed dementia had mild cognitive impairment on baseline examination. Baseline REM sleep atonia loss predicted development of dementia (% tonic REM = 73.2 ± 26.7 with dementia, 40.8 ± 34.5 without; P = 0.029). RBD at baseline also predicted the new development of hallucinations and cognitive fluctuations. In this prospective study, RBD was associated with increased risk of dementia. This indicates that RBD may be a marker of a relatively diffuse, complex subtype of PD. © 2012 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name></region><name sortKey="Bertrand, Josie Nne" sort="Bertrand, Josie Nne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name><name sortKey="Bertrand, Josie Nne" sort="Bertrand, Josie Nne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name><name sortKey="Desjardins, Catherine" sort="Desjardins, Catherine" uniqKey="Desjardins C" first="Catherine" last="Desjardins">Catherine Desjardins</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Panisset, Michel" sort="Panisset, Michel" uniqKey="Panisset M" first="Michel" last="Panisset">Michel Panisset</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Rios Romenets, Silvia" sort="Rios Romenets, Silvia" uniqKey="Rios Romenets S" first="Silvia" last="Rios Romenets">Silvia Rios Romenets</name><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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